The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A,B,C,DP,DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual eentries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginners guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclture and methods used for HLA typing. This book should provide an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing, and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markeres of human diversity.

Key Features

• Introductory chapters provide good general overview of HLA field for novice immunologists and geneticists
• Up-to-date, complete listing of HLA alleles
• Invaluable reference resource for immunologists, geneticists, and cell biologists
• Combines both structural and functional information, which has never been compiled in a single reference book previously

Entries provide information on:

• Current listing of alleles indentified
• Serological specificity of allotypes
• Identity of material sequenced including ethnic origin
• Database accession numbers
• pPopulation distribution
• Peptide binding specificities
• T-Cell epitopes
• Amino acid sequences of allotypes Key